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Test ID: TBGI Thyroxine-Binding Globulin (TBG), Serum

Reporting Name

Thyroxine Binding Globulin, S

Useful For

Determination of thyroxine-binding globulin levels is particularly useful for cases in which total thyroid hormone levels do not correlate with the thyrometabolic status, most commonly with pregnancy or the use of contraceptive steroids

Clinical Information

Thyroxine binding globulin (TBG) is the high-affinity serum binding protein for thyroxine and triiodothyronine. Normally, the thyroid adjusts to changing concentrations of TBG by producing more or less thyroid hormone to maintain a constant level of metabolically important free hormone.

 

Elevated TBG levels are associated with influences such as pregnancy, genetic predisposition, oral contraceptives, and estrogen therapy. TBG levels can decrease with androgenic or anabolic steroids, large doses of glucocorticoids, hypoproteinemic states, liver disease, nephrotic syndrome, and congenital TBG variants.            

 

Interpretation

A change in thyroxine-binding globulin (TBG) concentration may be of hereditary, pathophysiologic, or pharmacologic origin.

 

The TBG concentration indicates whether an abnormally high or low total thyroid hormone concentration is offset by a parallel increase or decrease in TBG concentration.

 

In TBG deficiency, one may find euthyroid patients with extremely low total thyroxine (T4) values. Conversely, patients with high TBG levels may be clinically euthyroid with high serum total T4 values.

 

Twenty-four specimens obtained during various stages of pregnancy yielded results ranging from 27 to 66 mcg/mL with a median of 43 mcg/mL. The literature suggests 47 to 59 mcg/mL as the range of TBG values expected during the third trimester of pregnancy.

Analytic Time

Same day/1 day

Day(s) and Time(s) Performed

Monday through Friday; 5 a.m.-3 p.m.

Saturday; 6 a.m.-3 p.m.

Clinical Reference

1. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Edited by CA Burtis, ER Ashwood, DE Bruns. 2006, pp 2053-2095

2. Wenzel KW: Pharmacological interference with in vitro tests of thyroid function. Metabolism 1981;30:717-732

Method Name

Solid-Phase Chemiluminescent Assay

Specimen Type

Serum


Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.35 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Reference Values

Males: 12-26 mcg/mL

Females: 11-27 mcg/mL

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84442

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TBGI Thyroxine Binding Globulin, S 3021-3

 

Result ID Test Result Name Result LOINC Value
TBGI Thyroxine Binding Globulin, S 3021-3
Mayo Clinic Laboratories | Endocrinology Catalog Additional Information:

mml-endo-thyroid