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Test ID: RGLUR Glucose, Random, Urine

Reporting Name

Glucose, Random, U

Useful For

An indicator of abnormal proximal tubule function

 

Limited usefulness in the screening or management of diabetes mellitus

Clinical Information

Under normal circumstances, glucose is readily filtered by glomeruli and the filtered glucose is reabsorbed by the proximal tubule; essentially no glucose is normally excreted in the urine. However, the capacity for the proximal tubule to reabsorb glucose is limited; if the filtered load exceeds the proximal tubule's reabsorptive capacity, a portion of the filtered glucose will be excreted in the urine. Thus, elevated serum glucose concentrations (as seen with diabetes mellitus) may result in an increase in filtered load of glucose and may overwhelm the tubules' reabsorptive capacity resulting in glucosuria. Glucosuria occurs when the renal threshold for glucose is exceeded (typically >180 mg/dL). This is most commonly, although not exclusively, seen in diabetes.

 

Additionally, conditions which adversely affect proximal tubule function may also result in decreased reabsorption of glucose, and increased urinary glucose concentration, even in the presence of normal plasma glucose concentrations. Some of these conditions include Fanconi syndrome, Wilson disease, hereditary glucosuria, and interstitial nephritis. These conditions are relatively rare, and most causes for elevated urine glucose concentrations are due to elevated serum glucose levels.

Interpretation

Elevated urine glucose concentration reflects either the presence of hyperglycemia or a defect in proximal tubule function.

 

As a screening test for diabetes mellitus, urine glucose testing has a low sensitivity (though reasonably good specificity).

Analytic Time

1 day

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Clinical Reference

Tietz Textbook of Clinical Chemistry, Third edition. Edited by CA Burtix, ER Ashwood. Philadelphia, WB Saunders Company, 1999

Method Name

Glucose Hexokinase

Specimen Type

Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube (T465)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

≤15 mg/dL

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82945

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RGLUR Glucose, Random, U 2350-7

 

Result ID Test Result Name Result LOINC Value
RGLUR Glucose, Random, U 2350-7
Mayo Clinic Laboratories | Endocrinology Catalog Additional Information:

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