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Test ID: GLUR Glucose, 24 Hour, Urine

Reporting Name

Glucose, U

Useful For

Limited usefulness in the screening or management of diabetes mellitus

Clinical Information

Under normal circumstances, glucose is readily filtered by glomeruli and the filtered glucose is reabsorbed by the proximal tubule; essentially no glucose is normally excreted in the urine. However, the capacity for the proximal tubule to reabsorb glucose is limited; if the filtered load exceeds the proximal tubule's reabsorptive capacity, a portion of the filtered glucose will be excreted in the urine. Thus, elevated serum glucose concentrations (such as occur with diabetes mellitus) may result in an increase in filtered load of glucose and may overwhelm the tubules' reabsorptive capacity resulting in glucosuria.

 

Additionally, conditions which adversely affect proximal tubule function may also result in decreased reabsorption of glucose, and increased urinary glucose concentration, even in the presence of normal plasma glucose concentrations. Some of these conditions include Fanconi syndrome, Wilson's disease, hereditary glucosuria, and interstitial nephritis. These conditions are relatively rare, and most causes for elevated urine glucose concentrations are due to elevated serum glucose levels.

Interpretation

Elevated urine glucose concentration reflects either the presence of hyperglycemia or a defect in proximal tubule function.

 

As a screening test for diabetes mellitus, urine glucose testing has a low sensitivity (though reasonably good specificity).

Analytic Time

1 day

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Clinical Reference

Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. Third edition, Philadelphia, PA. WB Saunders Company, 1999

Method Name

Glucose Hexokinase

Specimen Type

Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube (T465)

Specimen Volume: 4 mL

Collection Instructions:

1. Add 10 g of boric acid as preservative at start of collection.

2. Collect urine for 24 hours.

3. Mix well before taking 4-mL aliquot.

Additional Information:

1. 24-Hour volume is required.

2. See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

≤0.15 g/24 hours

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

82945

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GLUR Glucose, U 2351-5

 

Result ID Test Result Name Result LOINC Value
GLUU Glucose, U 2351-5
TM9 Collection Duration 13362-9
VL7 Urine Volume 3167-4
GLUCN Glucose Concentration 21305-8

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient

No

Refrigerate

OK

Frozen

OK

50% Acetic Acid

OK

Boric Acid

Preferred

Diazolidinyl Urea

No

6M Hydrochloric Acid

OK

6M Nitric Acid

OK

Sodium Carbonate

No

Thymol

OK

Toluene

No

Mayo Clinic Laboratories | Endocrinology Catalog Additional Information:

mml-diabetes-metabolic-nutrition