Test ID: GLUR Glucose, 24 Hour, Urine
Reporting Name
Glucose, UUseful For
Limited usefulness in the screening or management of diabetes mellitus
Clinical Information
Under normal circumstances, glucose is readily filtered by glomeruli and the filtered glucose is reabsorbed by the proximal tubule; essentially no glucose is normally excreted in the urine. However, the capacity for the proximal tubule to reabsorb glucose is limited; if the filtered load exceeds the proximal tubule's reabsorptive capacity, a portion of the filtered glucose will be excreted in the urine. Thus, elevated serum glucose concentrations (such as occur with diabetes mellitus) may result in an increase in filtered load of glucose and may overwhelm the tubules' reabsorptive capacity resulting in glucosuria.
Additionally, conditions which adversely affect proximal tubule function may also result in decreased reabsorption of glucose, and increased urinary glucose concentration, even in the presence of normal plasma glucose concentrations. Some of these conditions include Fanconi syndrome, Wilson's disease, hereditary glucosuria, and interstitial nephritis. These conditions are relatively rare, and most causes for elevated urine glucose concentrations are due to elevated serum glucose levels.
Interpretation
Elevated urine glucose concentration reflects either the presence of hyperglycemia or a defect in proximal tubule function.
As a screening test for diabetes mellitus, urine glucose testing has a low sensitivity (though reasonably good specificity).
Special Instructions
Analytic Time
1 dayDay(s) and Time(s) Performed
Monday through Sunday; Continuously
Clinical Reference
Tietz Textbook of Clinical Chemistry. Edited by CA Burtis, ER Ashwood. Third edition, Philadelphia, PA. WB Saunders Company, 1999
Method Name
Glucose Hexokinase
Specimen Type
UrineSpecimen Required
Container/Tube: Plastic, 5-mL tube (T465)
Specimen Volume: 4 mL
Collection Instructions:
1. Add 10 g of boric acid as preservative at start of collection.
2. Collect urine for 24 hours.
3. Mix well before taking 4-mL aliquot.
Additional Information:
1. 24-Hour volume is required.
2. See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.
Specimen Minimum Volume
1 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Urine | Refrigerated (preferred) | 7 days | |
Frozen | 7 days |
Reference Values
≤0.15 g/24 hours
Test Classification
This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82945
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
GLUR | Glucose, U | 2351-5 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
GLUU | Glucose, U | 2351-5 |
TM9 | Collection Duration | 13362-9 |
VL7 | Urine Volume | 3167-4 |
GLUCN | Glucose Concentration | 21305-8 |
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